Yang Fang(杨芳)

  教授/博导

Ph. D, Professor, Doctoral supervisor

State Key Laboratory of Bioelectronics

Jiangsu Key Laboratory for Biomaterials and Devices

School of Biological Science & Medical Engineering

SoutheastUniversity

Nanjing, Jiangsu, P. R. China 210096

Tel: 86-25-83272476-8009

Fax: 86-25-83272460

Email: yangfang2080@seu.edu.cn

 

Education Experience:

2006.3－2009.6  Biological Science & Medical Engineering, Southeast University, Ph.D Degree

2002.9－2004.6  Life College of Science and Engineering, ShaanXi University of Science & technology, Master Degree

2001.9－2002.7  Departments of Pharmaceutics, Shenyang Pharmaceutical University for pharmaceutics, Master Degree courses

1997.9－2001.7  Department of Food Science and Engineering, Northwest Institute of Light Industry, B.S Degree 

Research Experience:

2016.04－   School of Biological Science & Medical Engineering, Southeast University, Professor

2012.04－2016.04   School of Biological Science & Medical Engineering, Southeast University, Associate Professor

2013.12－2014.12   Department of Biomedical Engineering, University of Carlifornia, Davis, Visisting scholoar

2012.10－2012.12   Department of Chemistrey, The Univesity of Michigan, Visiting scholar

2009.09－2012.04   School of Biological Science & Medical Engineering, Southeast University, Lecturer 

Research Interestes:

• Fabrication novel microbubbles for multimodality biomedical imaging 
  

• Ultrasound imaging guided drug delivery
  

• Novel ultrasound sensitive micro-, nano- delivery system
  

• Ultrasonic theranostics 

Fundings:

• National Natural Science Foundation of China(31000453,31370019, 81971750) 

• National Key Basic Research Program of China (2013CB733804, 2018YFA0704103)

• Author of National Excellent Doctoral Dissertation of PR China (201259)

• Specialized Research Fund for the Doctoral Program of Higher Education of China (20100092120038)
  

• National Natural Science Foundation of Jiangsu Province (BK20191266)

 Selected Publications: 

2023年

[1] Jian Tang, Yang Liu, Mingxi Li, Xiao Wang, Anning Du, Ning Gu, Fang Yang*. Sphingosine‐1‐phosphate receptor targeted PLGA nanobubbles for inflammatory vascular endothelial cell catching. Adv. Healthcare Mater. 2023, https://doi.org/10.1002/adhm.202301407.

[2] Weiling Miao†, Yang Liu†, Jian Tang, Tiandong Chen, Fang Yang *. A Moexitecan Magnetic Liposomal Strategy for Ferroptosis-Enhanced Chemotherapy. Pharmaceutics 2023, 15: 2012.

[3] Yang Liu, Lin Cui, Xiao Wang, Weiling Miao, Yongxu Ju, Tiandong Chen, Huiting Xu, Ning Gu*, Fang Yang*. In situ nitric oxide gas nanogenerator reprograms glioma immunosuppressive microenvironment. Advanced Science, 2023, 10 (18): 2300679.

[4] Mingxi Li, Dongwen Deng, Zhe Chen, Wentao Liu, Gutian Zhao, Yu Zhang, Fang Yang*, Zhonghua Ni*. Magnetic nanoparticle loaded biodegradable vascular stents for magnetic resonance imaging and long-term visualization. Journal of Materials Chemistry B, 2023, 11, 3669-3678.

[5] Yongxu Ju, Huaijing Li, Jing Li, Ning Gu*, Fang Yang*. Dual-parameter cell biosensor for real-time monitoring of effects of propionic acid on neurons. Biosensor & Bioelectronics, 2023, 229: 115227.

[6] Haoli Yu, Yuesong Wang, Yan Chen, Mengyuan Cui, Fang Yang*, Peng Wang*, Min Ji*. Transmissible H-aggregated NIR-II fluorophore to the tumor cell membrane for enhanced PTT and synergistic therapy of cancer. Nano Convergence, 2023, 10(1): 3.

2022年

[1]Mingxi Li, Xiao Cheng, Zhe Chen, Zhonghua Ni, Ning Gu, Fang Yang*. Platelet magnetic nanocarriers as MRI sensors to delineate vascular injury network and targeted pre-protection in ischemic stroke. SCIENCE CHINA Materials, 2022, doi.org/10.1007/s40843-022-2177-x. 

[2] Jing Li, Yao Zhang, Zhichao Lou, Mingxi Li, Lin Cui, Zhenrong Yang, Lijuan Zhang, Yu Zhang, Ning Gu*, Fang Yang*. Magnetic Nanobubble Mechanical Stress Induces the Piezo1-Ca2+-BMP2/Smad Pathway to Modulate Neural Stem Cell Fate and MRI/Ultrasound Dual Imaging Surveillance for Ischemic Stroke. Small, 2022, 18(23): 2201123 (1-15). 

[3] Mingxi Li, Liang Wang, Dalin Tang, Gutian Zhao, Zhonghua Ni, Ning Gu*, Fang Yang*. Hemodynamic Mimic Shear Stress for Platelet Membrane Nanobubbles Preparation and Integrin αIIbβ3 Conformation Regulation. Nano Letters, 2022, 22(1): 271–279. 

[4] Li Yang, Bin Huang, Fang Yang*, Yan Li, Ning Gu*. Theoretical Study of the Effects of Nanoparticles on the Acoustic Performance of Microbubbles. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2022, 69(1): 54-61. 

[5] Yang Liu, Tiandong Chen, Ning Gu*, Fang Yang*. Recent progress in bioactive gas delivery for cancer immunotherapy. Progress in Biomedical Engineering, 2022, 4: 022001.

[6] Xin Liu, Yuxiang Sun, Bo Chen, Yan Li, Peng Zhu, Peng Wang, Sen Yan, Yao Li, Fang Yang*, Ning Gu*. Novel magnetic silk fibroin scaffolds with delayed degradation for potential long-distance vascular repair. Bioactive Materials, 2022, 7: 126-143.

2021年

[1] Yang Liu, Xiao Wang, Jing Li, Jian Tang, Bin Li, Yu Zhang, Ning Gu*, Fang Yang*. Sphingosine 1-Phosphate Liposomes for Targeted Nitric Oxide Delivery to Mediate Anticancer Effects against Brain Glioma Tumors. Advanced Materials, 2021, 33 (30): 2101701. 

[2] Jing Li, Zhenqiang Fen, Ning Gu*, Fang Yang*. Superparamagnetic iron oxide nanoparticles assembled magnetic nanobubbles and their application for neural stem cells labeling. Journal of Materials Science & Technology, 2021, 63: 124-132.

[3]Juan Jin, Mei Li, Jing Li, Bin Li, Lei Duan, Fang Yang*, Ning Gu*. Xenon Nanobubbles for the Image-Guided Preemptive Treatment of Acute Ischemic Stroke via Neuroprotection and Microcirculatory Restoration. ACS Applied Materials & Interfaces, 2021, 13: 43880-43891.

2020年

[1]Mingxi Li, Jing Li, Jinpeng Chen, Yang Liu, Xiao Cheng, Fang Yang*, Ning Gu*. Platelet Membrane Biomimetic Magnetic Nanocarriers for Targeted Delivery and in Situ Generation of Nitric Oxide in Early Ischemic Stroke. ACS Nano, 2020, 14: 2024-2035.

[2]Jiaxu Ding, Jing Li, Fang Yang*, Ning Gu*. A Multi-Channel System for Temperature Sensing of Neural Stem Cells in Adherent Culture. Anal. Chem. 2020, 92 (4): 3270-3275.

[3]Yue Zhou, Ning Gu*, Fang Yang*. In situ microbubble-assisted, ultrasound-controlled release of superparamagnetic iron oxide nanoparticles from gastro-retentive tablets. International Journal of Pharmaceutics, 2020,586: ‏ 11961.

[4] Siyu Wang, Xixi Guo, Weijun Xiu, Yang Liu, Lili Ren, Huaxin Xiao, Fang Yang, Yu Gao*, Chenjie Xu, Lianhui Wang*. Accelerating thrombolysis using a precision and clot-penetrating drug delivery strategy by nanoparticle-shelled microbubbles. Science Advances, 2020, 6(31): eaaz8204.

[5]Juan Jin, Fang Yang*, Bin Li, Dong Liu, Lihong Wu, Yan Li, Ning Gu*. Temperature-regulated self-assembly of lipids at free bubbles interface: a green and simple method to prepare micro/nano bubbles. Nano Research, 2020, 13(4): 999-1007.

[6] Li Yang, Bin Huang, Feng Chen, Juan Jin, Zhiguo Qin, Fang Yang*, Yan Li, Ning Gu*. Indocyanine Green Assembled Nanobubbles with Enhanced Fluorescence and Photostability. Langmuir, 2020, 36(43): 12983-12989.

[7]Zhiguo Qin, Bo Chen, Yu Mao, Chu Shi, Yan Li, Xiao Huang*, Fang Yang*, Ning Gu*. Achieving Ultrasmall Prussian Blue Nanoparticles as High-Performance Biomedical Agents with Multifunctions. ACS Appl. Mater. Interfaces 2020, 12 (51): 57382–57390. 

[8]Juan Jin, Ru Wang, Jian Tang, Li Yang, Zhenqiang Feng, Chunxiang Xu, Fang Yang*, Ning Gu*. Dynamic tracking of bulk nanobubbles from microbubbles shrinkage to collapse. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2020, 589: 124430(1-9). 

[9]Lei Duan, Li Yang, Juan Jin, Fang Yang*, Dong Liu, Ke Hu, Qinxin Wang, Yuanbin Yue, Ning Gu*. Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications. Theranostics. 2020, 10(2): 462-483. 

[10]Sen Ye, Yang Liu, Yi Lu, Yuqin Ji, Lianlian Mei, Mingwen Yang, Xiaoxuan Gong, Qian Gu, Di Li, Fang Yang*, Chun-Jian Li*. Cyclic RGD functionalized liposomes targeted to activated platelets for thrombosis dual-mode magnetic resonance imaging. Journal of Materials Chemistry B, 2020, 8(3), 447-453.

[11] Xinxing Chu, Jian Tang, Zhanli Geng, Xingya Wang, Gengyang Huo, Limin Zhou, Jing Wang, Kaiwei Yuan, Xiaodong Yang, Jun Hu*, Fang Yang*, Xingfei Zhou*, Lijuan Zhang*. Mechanical Properties of Sub-microbubbles with Nanoparticle-decorated Polymer Shell. Langmuir, 2020,35(52): 17090-17095. 

 2019年

[1] Zhiguo Qin, Bo Chen, Xiao Huang, Yu Mao, Yan Li, Fang Yang*, Ning Gu*. Magnetic internal heating-induced high performance Prussian blue nanoparticle preparation and excellent catalytic activity. Dalton Transactions, 2019, 48(46): 17169-17173. 

[2] Yang Liu, Jing Li, Heming Chen, Yan Cai, Tianyu Sheng, Peng Wang, Zhiyong Li, Fang Yang*, Ning Gu*. Magnet-activatable nanoliposomes as intracellular bubble microreactors to enhance drug delivery efficacy and burst cancer cells. Nanoscale, 2019, 11 (40): 18854-18865.

[3] Juan Jin, Zhenqiang Feng, Fang Yang*, Ning Gu*. Bulk Nanobubbles Fabricated by Repeated Compression of Microbubbles. Langmuir, 2019, 35(12): 4238-4245. 

[4] Taotao Liu, Mingxi Li, Jian Tang, Jing Li, Yue Zhou, Yang Liu, Fang Yang*, Ning Gu*. An acoustic strategy for gold nanoparticles loading in platelets as biomimetic multifunctional carriers. Journal of Materials Chemistry B, 2019, 7: 2138-2144. (Back cover)

 

2018年

[1] Mingxi Li, Yang Liu, Jinpeng Chen, Taotao Liu, Zhuxiao Gu, Jianqiong Zhang, Xiaochun Gu, Gaojun Teng, Fang Yang*, Ning Gu*. Platelet bio-nanobubbles as microvascular recanalization nanoformulation for acute ischemic stroke lesion theranostics. Theranostics, 2018, 8(18): 4870-4883. (SCI, IF: 8.537)

[2] Dong Liu, Zuoheng Zhang, Zhiguo Qin, Jing Xing, Yang Liu, Juan Jin, Fang Yang*, Ning Gu*. Sinapultide-loaded lipid microbubbles and the stabilization effect of sinapultide on the shell of lipid. Journal of Materials Chemistry B, 2018, 6(9): 1335-1341.(SCI, IF: 4.543)

[3] Juan Jin#, Taotao Liu#, Mingxi Li, Chuxiao Yuan, Yang Liu, Jian Tang, Zhenqiang Feng, Yue Zhou, Fang Yang*, Ning Gu*. Rapid in situ biosynthesis of gold nanoparticles in living platelets for multimodal biomedical imaging. Colloids and Surfaces B: Biointerfaces, 2018, 163: 385-393. (SCI, IF: 3.887) 

2017年

[1] Yang Liu, Mingxi Li, Fang Yang*, Ning Gu*. Magnetic drug delivery systems. Science Materials-China, 2017, 60(6): 471-486. (SCI, IF=3.956)

[2] Tuantuan Wang, Chuxiao Yuan, Bingyang Dai, Yang Liu, Mingxi Li, Zhenqiang Feng, Qing Jiang, Zhihong Xu, Ningwei Zhao, Ning Gu*, Fang Yang*. Click chemistry-mediated rapid microbubble catching for acute thrombus ultrasound molecular imaging. ChemBioChem, 2017,18, 1364-1368. (SCI, IF=2.850)

[3] Yang Liu, Fang Yang*, Chuxiao Yuan, Mingxi Li, Tuantuan Wang, Bo Chen, Juan Jin, Peng Zhao, Jiayi Tong, Shouhua Luo, Ning Gu*. Magnetic Nanoliposomes as In Situ Microbubble Bombers for Multimodality Image-Guided Cancer Theranostics. ACS Nano, 2017, 11(2): 1509-1519 (SCI, IF=13.334)

[4] Dong Liu, Jing Xing, Fei Xiong, Fang Yang*, Ning Gu*. Preparation and in vivo safety evaluations of antileukemic homoharringtonine-loaded PEGylated liposomes. Drug Development and Industrial Pharmacy, 2017, 43(4): 652-660. http://dx.doi.org/10.1080/03639045.2016.1275670. (SCI, IF=2.429)

 

2016年

[1] Lei Duan^#, Fang Yang^#, Wen He, Lina Song, Fan Qiu, Ning Xu, Lu Xu, Yu Zhang, Zichun Hua*, Ning Gu*. A multi-gradient targeting drug delivery system based on RGD-L-TRAIL -Labeled magnetic microbubbles for cancer theranostics. Advanced Functional Materials, 2016, 26, 8313-8324.(Co-first author)

[2] Dong Liu, Fang Yang*, Fei Xiong, Ning Gu*. The smart drug delivery system and its clinical potential. Theranostics, 2016, 6(9): 1306-1323.

[3] Galina Shapiro, Andrew W. Wong, Maxim Bez, Fang Yang, Sarah Tam, Lisa Even, Dmitriy Sheyn, Shiran Ben-David, Wafa Tawackoli, Gadi Pelleda, Katherine W. Ferrara, Dan Gazit. Multiparameter evaluation of in vivo gene delivery using ultrasound-guided, microbubble-enhanced sonoporation. Journal of Controlled Release, 2016, 223: 157-164.

[4] Fang Yang*, Mingxi Li, Yang Liu, Tuantuan Wang, Zhenqiang Feng, Huating Cui, Ning Gu*, Glucose and magnetic-responsive approach toward in situ nitric oxide bubbles controlled generation for hyperglycemia theranostics, Journal of Controlled Release, 2016, 228: 87-95.

[5] Fangfang Shi, Fang Yang, Xiangfeng He, Ying Zhang, Songyan Wu, Miao Li, Yunxia Zhang, Wu Di, Jun Dou, Ning Gu. Inhibitory effect of epirubicin-loaded lipid microbubbles with conjugated anti-ABCG2 antibody combined with therapeutic ultrasound on multiple myeloma cancer stem cells. J Drug Target, 2016, 24(1): 34-46.

~2015年

[1] Fang Yang, Xiaoxian Zhang*, Lina Song, Huating Cui, John N. Myers, Tingting Bai, Ying Zhou, Zhan Chen*, Ning Gu*. Controlled Drug Release and Hydrolysis Mechanism of Polymer–Magnetic Nanoparticle Composite. ACS Appl. Mater. Interfaces, 2015, 7 (18): 9410-9419.

[2] Kun Fang, Lina Song, Zhuxiao Gu, Fang Yang*, Yu Zhang, Ning Gu*, Magnetic field activated drug release system based on magnetic PLGA microspheres for chemo-thermal therapy, Colloids and Surfaces B: Biointerfaces 2015, 136, 712-720.

[3] Jilai Tian, Fang Yang*, Huating Cui, Ying Zhou, Xiaobo Ruan, Ning Gu*. A novel approach to making the gas-filled liposome real: based on the interaction of lipid with free nanobubbles within the solution. ACS Appl. Mater. Interfaces, 2015, 7 (48): 26579-26584.

[4] Lei Duan, Fang Yang, Lina Song, Kun Fang, Jilai Tian, Yijun Liang, Mingxi Li, Ning Xu, Zhongda Chen, Yu Zhang, Ning Gu*. Controlled assembly of magnetic nanoparticles on microbubbles for multimodal imaging. Soft Matter, 2015, 11, 5492-5500.

[5] Fangfang Shi, Fang Yang, Xiangfeng He, Ying Zhang, Songyan Wu, Miao Li, Yunxia Zhang, Wu Di, Jun Dou, Ning Gu. Inhibitory effect of epirubicin-loaded lipid microbubbles with conjugated anti-ABCG2 antibody combined with therapeutic ultrasound on multiple myeloma cancer stem cells. J Drug Target, 2016, 24(1):34-46.

[6] Fang Yang, Mingxi Li, Huating Cui, Tuantuan Wang, Zhongwen Chen, Lina Song, Zhuxiao Gu, Yu Zhang, Ning Gu*. Altering the response of intracellular reactive oxygen to magnetic nanoparticles using ultrasound and microbubbles. SCIENCE CHINA Materials, 2015, 58(6): 467-480.

[7] Kun Fang, Fang Yang, Qiying Zhang, Tianzhu Zhang, Ning Gu*. Fabrication of nonporous and porous cationic PLGA microspheres, Materials Letters, 2014, 117(15): 86-89.

[8] Fang Yang^*, Qing Wang, Zhuxiao Gu, Kun Fang, Gerard Marriott, Ning Gu*. Silver nanoparticle-embedded micro-bubble as a dual-mode ultrasound and optical imaging probe. ACS Appl. Mater. Interfaces, 2013, 5 (18): 9217–9223.

[9] Fang Yang, Sunling Hu, Yu Zhang, Xiaowei Cai, Yan Huang, Feng Wang, Song Wen, Gaojun Teng, Ning Gu*. A Hydrogen Peroxide-Responsive O₂ Nanogenerator for Ultrasound and Magnetic-Resonance Dual Modality Imaging. Adv. Mater. 2012, 24(38): 5205–5211.

[10] Xiaowei Cai, Fang Yang, Ning Gu*. Applications of Magnetic Microbubbles for Theranostics. Theranostics, 2012; 2(1):103-112.

[11] Wen He, Fang Yang, Yihang Wu, Song Wen, Ping Chen, Yu Zhang, Ning Gu*. Microbubbles with surface coated by superparamagnetic iron oxide nanoparticles. Materials Letters, 2012, 68(1): 64-67.

[12] Fang Yang, Miao Zhang, Wen He, Ping Chen, Xiaowei Cai, Li Yang, Ning Gu*, Junru Wu. Controlled Release of Fe₃O₄ Nanoparticles in Encapsulated Microbubbles to Tumor Cells via Sonoporation and Associated Cellular Bioeffects, Small 2011, 7(7), 902–910

[13] Fang Yang, Ping Chen, Wen He, Ning Gu*, Xizhi Zhang, Kun Fang, Yu Zhang, JianFei Sun, Jiayi Tong. Bubble Microreactors Triggered by an Alternating Magnetic Field as Diagnostic and Therapeutic Delivery Devices. Small, 2010, 6(12): 1300-1305.

[14] Fang Yang, Yixin Li, Zhongpin Chen, Yu Zhang, Junru Wu, Ning Gu*. Superparamagnetic Iron Oxide Nanoparticle-embedded Encapsulated Microbubbles as Dual Magnetic Resonance and Ultrasound Imaging Contrast Agents. Biomaterials, 2009, 30(23-24):3 882-3890.

[15] Fang Yang, Ning Gu*, Di Chen, Xiaoyu Xi, Dong Zhang, Yixin Li, Junru Wu. Experimental study on cell self-sealing during sonoporation. Journal of Controlled Release, 2008, 131(3): 205-210.