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posted on 2022-04-01, 17:35 authored by Damiano Fassina, Caroline M. Costa, Stefano Longobardi, Elias Karabelas, Gernot Plank, Sian E. Harding, Steven A. NiedererValue ranges of the 10 parameters (rows) used in the two versions of our model (Epi-endo, and Endo-epi, 1st and 2nd columns respectively). The 3 sub-cases (Transmural, Block and Fixed) are shown in the 3rd, 4th and 5th columns. The table shows which parameters of the original model are fixed in order to derive each sub-case. The bottom row displays representations of each model version and subcases.
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sup >+ key step toward global sensitivity analysis epicardial patches constructed consistent across species cardiac myocyte electrophysiology associated arrhythmic risk restoring physiological activation recovered physiological activation match healthy activation increased arrhythmia risk epicardial patch spanning eht patches observed restore physiological propagation stimulus propagation paths transmural cross section successful patch engraftment small animal studies patch geometrical dimensions mi activation properties gsa sensitivity indices eht design variables div >< p cms immature phenotype cardiac electrophysiology model tuning eht conductivity 1 – 1 may restore pre understanding electrical interaction increasing eht conductivity eht patch conductivity host myocardium represents stimulus propagation restore pre electrical activation patch design mi activation eht conductivity tested increasing may lead increased na engraftment site eht na mi ). host myocardium tissue dimensions vitro term therapy small animals simulations predict silico scale differences results revealed qualitatively reproduce model suggests model revealed model featured mainly governed infarct region important parameters derived cardiomyocytes cp ). conductive polymer comparing simulations channel density bath region alternative strategy aid non
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